NDC 80425-0016 Oral Tablet, Film Coated Flexeril Drug Codes, Packaging, Active Ingredients
Also, cyclobenzaprine can cause dry mouth because it has anticholinergic effects. Cyclobenzaprine belongs to a class of drugs called muscle relaxants. A class of drugs is a group of medications that work in a similar way. The recommended dose of immediate-release cyclobenzaprine is 5 to 10mg, three times a day, while that for extended-release versions is 15 to 30 mg, once a day. Maximum daily dose for either form is 30 mg over the course of 24 hours. Taking more may result in adverse Flexeril side effects or overdose.
Less frequent dosing should be considered for hepatically impaired or elderly patients (see PRECAUTIONS, Impaired Hepatic Function, and Use in the Elderly). All patients suspected of an overdose with FLEXERIL should receive gastrointestinal decontamination. This should include large volume gastric lavage followed by activated charcoal. If consciousness is impaired, the airway should be secured prior to lavage and emesis is contraindicated. It is not known whether this drug is excreted in human milk. Because cyclobenzaprine is closely related to the tricyclic antidepressants, some of which are known to be excreted in human milk, caution should be exercised when FLEXERIL is administered to a nursing woman.
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The biggest difference between cyclobenzaprine and tizanidine is the difference between short and long-term care. Because cyclobenzaprine isn’t effective for longer than two weeks, it’s not as useful for long-term issues like neurological disorders like cerebral palsy. The drug can be used with physical therapy, which helps strengthen muscles and lead to lasting improvements within that two-week span. Chlorzoxazone assists in managing muscle spasms by depressing the reflexes involved in producing these painful contractions.
Tricyclic antidepressants have been reported to produce arrhythmias, sinus tachycardia, prolongation of the conduction time leading to myocardial infarction and stroke. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Avoid driving or hazardous activity until you know how cyclobenzaprine will affect you. Call your doctor if your symptoms do not improve after 3 weeks, or if they get worse. Older adults may be more sensitive to the effects of this medicine.
- Yes, you can overdose on Flexeril — including cyclobenzaprine 10 mg dose.
- If you’re currently recovering from an injury and undergoing physical therapy, check with your therapist before adopting a new exercise routine.
- Because cyclobenzaprine isn’t effective for longer than two weeks, it’s not as useful for long-term issues like neurological disorders like cerebral palsy.
Cyclobenzaprine is a muscle relaxer used to treat muscle spasms and acute muscle pain. It’s not intended for long-term use or to treat chronic pain. Cyclobenzaprine and muscle relaxers like it are usually prescribed following an injury, car accident, or another minor incident that causes muscle spasms and other temporary muscle conditions. It can also enhance the effects of agents with CNS depressant activity.
The incidence of drowsiness, the most frequent adverse reaction, was similar with both drugs. Eight double-blind controlled clinical studies were performed in 642 patients comparing tylenol and flexeril together, diazepam, and placebo. Muscle spasm, local pain and tenderness, limitation of motion, and restriction in activities of daily living were evaluated.
Less commonly, tachycardia, dysarthria, disorientation, and hallucinations have been reported . Drug comparisons between cyclobenzaprine and methocarbamol in terms of side effects do not reveal many differences. Both medications can cause adverse effects such as dizziness, drowsiness, headache, nausea, and fatigue. Cyclobenzaprine tends to cause more drowsiness than methocarbamol.
Protect the patient’s airway, establish an intravenous line and initiate gastric decontamination. Observation with cardiac monitoring and observation for signs of CNS or respiratory depression, hypotension, cardiac dysrhythmias and/or conduction blocks, and seizures is necessary. If signs of toxicity occur at any time during this period, extended monitoring is required. Monitoring of plasma drug levels should not guide management of the patient. Dialysis is probably of no value because of low plasma concentrations of the drug. In the higher dose groups this microscopic change was seen after 26 weeks and even earlier in rats which died prior to 26 weeks; at lower doses, the change was not seen until after 26 weeks.
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Properly discard this product when it is expired or no longer needed. This medication has been prescribed for your current condition only. Do not use it later for another condition unless your doctor directs you to do so. Alcohol or marijuana (cannabis) can make you more dizzy or drowsy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely.
Can You Overdose on Cyclobenzaprine (Flexeril)?
Multiple drug ingestion (including alcohol) is common in deliberate cyclobenzaprine overdose. As management of overdose is complex and changing, it is recommended that the physician contact a poison control center for current information on treatment. Signs and symptoms of toxicity may develop rapidly after cyclobenzaprine overdose; therefore, hospital monitoring is required as soon as possible. The acute oral LD50 of FLEXERIL is approximately 338 and 425 mg/kg in mice and rats, respectively. The plasma concentration of cyclobenzaprine is increased in the elderly (see CLINICAL PHARMACOLOGY, Pharmacokinetics, Elderly).